16 publications
This study explores neutralization by antibody fragment VH ab6 against major SARS-CoV-2 variants, revealing structural insights into spike mutations and antibody evasion.
Read paperThis review details structural biology and pathobiology of SARS-CoV-2, focusing on its life cycle and imaging techniques that advance our understanding of viral entry and replication.
Read paperThis study evaluates the Delta and Kappa variants’ structural and biochemical fitness, highlighting their antibody escape mechanisms and ACE2 binding dynamics.
Read paperMannar, Saville, Zhu, Srivastava, Berezuk, Tuttle, Marquez, Sekirov, and Subramaniam present the cryo-EM structure of the SARS-CoV-2 Omicron variant spike protein bound to human ACE2, revealing how mutations allow antibody evasion and maintain receptor binding. This study offers insight into Omicron’s rapid spread and immune resistance.
Read paperThis study investigates key mutations in SARS-CoV-2 variants that enhance ACE2 binding and promote antibody evasion through structural analyses.
Read paperThis 2.9-Å cryo-EM study reveals N501Y’s interaction with ACE2, enhancing infectivity without compromising antibody binding.
Read paperThis study presents a cryo-EM structure of the N501Y spike protein of the UK variant of SARS-CoV-2, showing how the mutation increases infectivity while retaining neutralizing antibody binding sites.
Read paperA novel human antibody domain, VH ab8, was developed showing strong neutralizing effects against SARS-CoV-2 in mice and hamsters. Its small size and bivalency made it highly effective in targeting the virus and blocking ACE2 interaction, positioning it as a promising COVID-19 therapeutic.
Read paperThis study reports cryo-EM structures of Plasmodium vivax hexokinase (PvHK), revealing a unique tetrameric organization that is distinct from human hexokinases, providing insights for the design of parasite-selective antimalarial drugs.
Read paperThis study explores the role of a βγ-crystallin domain in modulating the enzymatic activity of a glycoside hydrolase, glucanallin, and its potential application in biofuel production from β-1,3-glucans.
Read paperThis study investigates how interdomain interactions in the abundant perithecial protein (APP) of *Neurospora crassa* render its Ca2+-binding site inactive, revealing a novel mode of Ca2+-binding regulation in proteins with both βγ-crystallin and Ig-like domains.
Read paperThis study reveals that Methallin, a βγ-crystallin from Methanosaeta thermophila, is a trimeric, transition metal-binding protein, providing new insights into its potential biogeochemical roles and high-affinity metal ion binding.
Read paperThis review highlights microbial βγ-crystallins as a diverse superfamily of Ca2+-binding proteins, noting their evolutionary adaptations and the need for experimental characterization.
Read paperThis study investigates the βγ-crystallin-type double clamp motif for Ca2+ binding, highlighting its structural diversity and potential functional implications.
Read paperThis study investigates the unfolding pathways of βγ-crystallins and the formation of an aggregation-prone intermediate state in the Crybg3_D3 domain, offering insights into its structural and functional divergence in non-lens tissues of vertebrates.
Read paperThis study analyzes Ca²⁺ binding in βγ-crystallin motifs, identifying binding determinants and stability gains through detailed structural investigations.
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