+91 9674810412 shanti@iiserbpr.ac.in
Research

Protein Phosphatase 2A (PP2A)

Decoding its intricate molecular framework to uncover how it orchestrates chromatin architecture, modulates cell survival, and drives critical signaling pathways.

Project Overview

Protein Phosphatase 2A (PP2A) is a critical regulatory enzyme involved in maintaining cellular balance through its role in dephosphorylation. It is essential for processes like cell cycle control and signal transduction.

This project aims to provide a generalized understanding of PP2A’s structural and functional properties using a combination of computational and experimental techniques. Our focus is to explore its overall role in cellular regulation without revealing detailed mechanisms.

Key Objectives

  • Assess the overall structural features of PP2A.
  • Explore its general role in cellular regulation.
  • Examine its interactions with other cellular proteins.
  • Evaluate its potential implications in disease contexts.

Significance

Gaining a generalized understanding of PP2A is vital for appreciating its role in maintaining cellular homeostasis and its potential as a target in therapeutic research.